P0742 - Nationwide Population-Based Study of the Outcomes of Cardiac Troponin Elevation in Patients With Acute GI Bleed

Anwar Uddin, MD¹, Nazeera Ghanie, MD², Peter Lymberopoulos, MD¹, Prashil Dave, MD³, Madia Ahad, MD¹, Rafat Uddin, BA¹, Rahat Uddin, MS¹, Afgal Ahad, MD¹, Dipsa Shastri, MD⁴, Sahil Chaddha, MD, MS¹, Abena Agyekum, MD², Nana Osei, MD², Narinderjeet Kaur, MD, MS¹, Isabel Conde, MD³, Rita Offor, MD¹, Ammar Abdulfattah, MD¹, Sahil Zaveri, MD², Syeda M. Ali, MD^1
1SUNY Downstate Medical Center, Brooklyn, NY; ²SUNY Downstate Health Sciences University, Brooklyn, NY; ³State University of New York Downstate, Brooklyn, NY; ⁴East Tennessee State University, Johnson City, TN

Introduction: Elevation of cardiac troponin (cTn) can happen in patients with non-cardiac illnesses including acute gastrointestinal bleeding (AGIB). There is limited evidence available regarding the outcomes of cTn elevation associated with AGIB. The aim of present study is to examine the outcomes of cTn elevation in patients admitted with AGIB.

Methods: We used the Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) to identify adult patients admitted with AGIB during 2016 – 2020 using ICD-10-CM codes. We divided the patients into two groups based on concomitant diagnosis of cTn elevation based on ICD-10-CM codes (defined as having ICD-10-CM codes of Type 2 MI, I21.A1, or other forms of acute ischemic heart disease, I24.8). Main outcomes were in-hospital mortality, length of stay (LOS), and hospital costs. We evaluate the association between cTn elevation and outcomes using survey based multivariate logistic regression models for in-hospital mortality, Poisson regression for LOS, and generalized linear model with gamma distribution and log link for hospitalization cost. Models were adjusted for age, sex, race and ethnicity, primary payer, Charlson comorbidity index, hospital bed size, hospital region and hospital teaching status.

Results: We identified a total of 4,637,194 AGIB hospitalizations between 2016 and 2020 in the United States and 171,015 (3.7%) of them were associated with cTn elevation (Table 1). In‐patient mortality was significantly higher in AGIB patients with cTn elevation (13.0% vs 6.1%, adjusted OR: 1.83, 95%CI: 1.77 - 1.90, P < 0.001, Table 2). AGIB patients with cTn elevation had an increased length of stay (9.1 ± 0.07 vs 6.4 ± 0.02 days, P < 0.001) and cost of hospitalization ($30,440 ± 331 vs $19,422 ± 113, P < 0.001, Table 2).

Discussion: cTn elevation in patients with AGIB is associated with higher in‐hospital mortality, increased length of stay, and increased cost of hospitalization. Further studies will need to be conducted to understand the relationship between cTn and AGIB.



Disclosures:


Anwar Uddin, MD¹, Nazeera Ghanie, MD², Peter Lymberopoulos, MD¹, Prashil Dave, MD³, Madia Ahad, MD¹, Rafat Uddin, BA¹, Rahat Uddin, MS¹, Afgal Ahad, MD¹, Dipsa Shastri, MD⁴, Sahil Chaddha, MD, MS¹, Abena Agyekum, MD², Nana Osei, MD², Narinderjeet Kaur, MD, MS¹, Isabel Conde, MD³, Rita Offor, MD¹, Ammar Abdulfattah, MD¹, Sahil Zaveri, MD², Syeda M. Ali, MD¹. P0742 - Nationwide Population-Based Study of the Outcomes of Cardiac Troponin Elevation in Patients With Acute GI Bleed, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.