P0929 - Impact of Comorbid Heart Failure Among Hospitalized Patients With Crohn's Disease: A United States Population-Based Cohort Study

Karecia Byfield, MBBS¹, Thanathip Suenghataiphorn, MD², Phuuwadith Wattanachayakul, MD¹, John Malin, DO¹, Pojsakorn Danpanichkul, MD³, Chawin Lopimpisuth, MD⁴, Pakin Lalitnithi, MD⁵, Natchaya Polpichai, MD⁶, Sakditad Saowapa, MD³, Bruce Adrian Casipit, MD⁷, Carlo Gabriel C. Casipit, MD¹, Natapat Chaisidhivej, MD⁸, Mikaela Nikkola Jara-Tantoco, MD^1
1Albert Einstein Medical Center, Philadelphia, PA; ²Griffin Hospital, Derby, CT; ³Texas Tech University Health Sciences Center, Lubbock, TX; ⁴University of Miami Miller School of Medicine, Miami, FL; ⁵St. Elizabeth’s Medical Center, Boston, MA; ⁶Weiss Memorial Hospital, Chicago, IL; ⁷Einstein Medical Center, Philadelphia, PA; ⁸University of Nebraska Medical Center, Omaha, NE

Introduction: Recent studies have highlighted the adverse outcomes of cardiovascular disorders in individuals with inflammatory bowel disease. However, there is a lack of data regarding the influence of concomitant heart failure (HF), specifically on the outcome among patients primarily hospitalized with Crohn’s disease (CD).

Methods: We analyzed the 2020 U.S. National Inpatient Sample (NIS) to explore the impact of comorbid heart failure (HF) on patients admitted with CD. Participants aged 18 and older were identified using relevant ICD-10 CM codes for CD and other comorbidities. We used multivariable logistic and linear regression analyses to determine the association between comorbid HF and hospital-related outcomes in CD patients.

Results: We identified 8,783 patients diagnosed with CD as their primary discharge diagnosis. The mean age of the cohort was 42±18 years, and 53.5% were female. Caucasian accounted for 73%, followed by Black (16%), Mexican American (7%), and Asian (1%). Of the total, 2.78% (244/8,783) had a concurrent diagnosis of HF. Upon adjusting for baseline demographic data and hospital-level confounders, comorbid HF was significantly associated with a longer length of stay (LOS), as indicated by a beta-coefficient (β_LOS) of 1.58 (β_LOS: 1.58, P < 0.001). Additionally, individuals with comorbid HF were 2.20 times more likely to experience acute kidney injury (AKI) (aOR_AKI 2.20, P < 0.001). However, other outcomes, including a higher mortality risk (aOR_mortality1.03, P 0.963), shock requiring vasopressor administration (aOR_shock 2.21, P 0.531), utilization of mechanical ventilation (aOR_vent 1.07, P 0.890), the occurrence of lower GI bleeding (aOR_LGIB 1.03, P 0.963), and anemia (aOR_anemia 1.10, P 0.678), were observed but did not reach statistical significance.

Discussion: In summary, our study indicates that comorbid HF in hospitalized CD patients is linked to a higher risk of AKI and prolonged LOS. Longitudinal cohort studies are required to further elucidate the relationship.


Disclosures:


Karecia Byfield, MBBS¹, Thanathip Suenghataiphorn, MD², Phuuwadith Wattanachayakul, MD¹, John Malin, DO¹, Pojsakorn Danpanichkul, MD³, Chawin Lopimpisuth, MD⁴, Pakin Lalitnithi, MD⁵, Natchaya Polpichai, MD⁶, Sakditad Saowapa, MD³, Bruce Adrian Casipit, MD⁷, Carlo Gabriel C. Casipit, MD¹, Natapat Chaisidhivej, MD⁸, Mikaela Nikkola Jara-Tantoco, MD¹. P0929 - Impact of Comorbid Heart Failure Among Hospitalized Patients With Crohn's Disease: A United States Population-Based Cohort Study, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.