P0935 - Serum Interleukin 17 Levels in Ulcerative Colitis and Crohn’s Disease: Inflammatory Bowel Disease Patients in Indonesia

Muhammad F. Prananda, MD¹, Murdani Abdullah, MD, PhD, FACG², Sukamto Koesnoe, MD, PhD², Robert Sinto, MD^2
1Universitas Indonesia, East Jakarta, Jakarta Raya, Indonesia; ²Universitas Indonesia, Central Jakarta, Jakarta Raya, Indonesia

Introduction: The incidence of IBD is increasing worldwide, with different characteristics in each country. IL-17 is a strong pro-inflammatory cytokine that plays a role in IBD. No studies have assessed serum interleukin 17 (IL-17) levels in IBD patients in Indonesia, which can reveal its role in the pathogenesis of IBD as well as proposed therapeutic modalities for IBD. This study aimed to determine the difference in serum IL-17 levels in patients with IBD.

Methods: We conducted a cross-sectional study at Cipto Mangunkusumo National General Hospital from April 2022 to April 2023. The inclusion criteria were adult patients diagnosed with IBD and a healthy population who did not have any gastrointestinal complaints or a history of autoimmune diseases and malignancies. Data collection was carried out sequentially. Serum IL-17 levels were assessed using ELISA. Mann-Whitney tests and linear regression were carried out using the SPSS application.

Results: The total number of subjects in this study was 125, consisting of 93 IBD patients and 32 healthy subjects. Serum IL-17 levels were 4.13 (3.19-5.14), 4.30 (3.59-5.14), and 3.40 (2.97-4.01) pg/mL for the ulcerative colitis (UC), Crohn’s disease (CD), and healthy subjects (p=0.004). There was no difference of serum IL-17 levels between UC and CD. Multivariate analysis showed that disease activity (p=0.010) is associated with serum IL-17 levels in UC.

Discussion: There was a significant difference in the median value of serum IL-17 levels between IBD and healthy population, but there was no differences between UC and CD.


Disclosures:


Muhammad F. Prananda, MD¹, Murdani Abdullah, MD, PhD, FACG², Sukamto Koesnoe, MD, PhD², Robert Sinto, MD². P0935 - Serum Interleukin 17 Levels in Ulcerative Colitis and Crohn’s Disease: Inflammatory Bowel Disease Patients in Indonesia, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.