N.R.I Medical College GUNTUR, Andhra Pradesh, India
Award: Presidential Poster Award
Amit Banerjee, MBBS1, Jobby John, MBBS2, Pragathi Munnangi, MBBS3, Lalitkumar Patel, MBBS4, Venkata Ramana Katikala, MBBS5, SIRI VUMMANENI, MBBS6, Himanshu Koyani, MBBS, MS7, George Mathew Mukalil, MD8, Bhargav Koyani, MD9, Simranpreet Singh Daid, MBBS10, Hardik Dineshbhai. Desai, MBBS11, Tanvi Koduru, BS12 1Stanley Medical College, Chennai, Tamil Nadu, India; 2Dr. Somervell Memorial CSI Medical College & Hospital Karakonam, Thiruvananthapuram, Kerala, India; 3N.R.I Medical College, Guntur, Andhra Pradesh, India; 4Suburban Medical Center, Schaumburg, IL; 5Konaseema Institute of Medical Sciences and Research Foundation, McKinney, TX; 6Sri Devaraj Urs Medical College, Kolar, Karnataka, India; 7Sterling Hospital, Rajkot, Gujarat, India; 8Central Michigan University, Saginaw, MI; 9Saint Francis Hospital, Evanston, Evanston, IL; 10Punjab Institute of Medical Sciences, Abohar, Punjab, India; 11Gujarat Adani Institute of Medical Sciences, Ahmedabad, Gujarat, India; 12Bergen Community College, Paramus, NJ
Introduction: Liver cancer (LC) is a 7th leading cause of death amongst all cancer related causalities, with incidence rates influenced by various risk factors including viral hepatitis and lifestyle choices. Emerging evidence identifies drug use, especially injectable drugs, as a significant risk factor due to its role in the transmission of hepatitis B and C, leading precursors to hepatocellular carcinoma. Despite the known links, research specifically quantifying the burden of LC attributable to Drug use remains limited.
Methods: This is the first ever study identifying deaths, years lived with disability (YLDs), years of life lost (YLLs) due to LC attributable to drug use by age, sex, year and location across the 204 Countries and territories from 1990-2021 using global burden of disease 2021 tool.
Results: The total number of deaths rose from 17,090 (95% uncertainty interval: 12,161-23,510) in 1990 to 65,499 (50,430-83,777) in 2021. Regionally, Southern Latin America experienced the largest increase in age-standardized death rate (ASMR), surging by 532%, followed by Australasia at 452%, and Southern Sub-Saharan Africa at 245% between 1990 and 2021. Nationally, Canada saw the greatest annual percentage change (APC) in ASMR, increasing by 14.3%, with Greenland next at 8.65% over the same period. In terms of the Socio-Demographic Index, the highest ASMR was recorded in high SDI countries at 1.14 (0.92-1.38) cases per 100,000 person years in 2021, followed by YLDs at 0.37 (0.25-0.53) and YLLs at 27.58 (22.84-33.34) per 100,000. By age, those under 20 years old showed the highest total percentage change (TPC) in unadjusted death rate at 207%, followed by those aged 55 and older at 98%, and those aged 20-54 at 33% from 1990 to 2021. In terms of gender, TPC in total deaths was 258% for males versus 348% for females, YLDs were 295% for males versus 385% for females, and YLLs were 191% for males versus 276% for females between 1990 and 2021.
Discussion: Deaths due to LC attributable to Drug use accounted for 13.53% of all LC related deaths in 2021 highlights a critical and preventable public health challenge. This emphasizes the urgent need for comprehensive drug prevention and treatment programs, alongside routine screenings within healthcare settings. By addressing drug use robustly, we can significantly reduce the burden of liver cancer and improve public health outcomes.
Figure: A: Global Trend of Liver Cancer Attributable to Drug Use in 204 Countries and Territories from 1990-2021, B: Age-wise Burden of Liver Cancer Attributable to Drug Use in 204 Countries and Territories in Year 1990 and Year 2021, C: GBD Region wise Burden of Liver Cancer Attributable to Drug Use, Age-Standardized Rate (Per 100,000)
Disclosures:
Amit Banerjee indicated no relevant financial relationships.
Jobby John indicated no relevant financial relationships.
Pragathi Munnangi indicated no relevant financial relationships.
Lalitkumar Patel indicated no relevant financial relationships.
Venkata Ramana Katikala indicated no relevant financial relationships.
SIRI VUMMANENI indicated no relevant financial relationships.
Himanshu Koyani indicated no relevant financial relationships.
George Mathew Mukalil indicated no relevant financial relationships.
Bhargav Koyani indicated no relevant financial relationships.
Simranpreet Singh Daid indicated no relevant financial relationships.
Hardik Desai indicated no relevant financial relationships.
Tanvi Koduru indicated no relevant financial relationships.
Amit Banerjee, MBBS1, Jobby John, MBBS2, Pragathi Munnangi, MBBS3, Lalitkumar Patel, MBBS4, Venkata Ramana Katikala, MBBS5, SIRI VUMMANENI, MBBS6, Himanshu Koyani, MBBS, MS7, George Mathew Mukalil, MD8, Bhargav Koyani, MD9, Simranpreet Singh Daid, MBBS10, Hardik Dineshbhai. Desai, MBBS11, Tanvi Koduru, BS12. P1159 - Mapping the Global Impact: Liver Cancer Attributable to Drug Use Across 204 Countries, 1990-2021: A Benchmarking Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
