University of Florida College of Medicine Jacksonville, FL
Landen Shane Burstiner, DO, MSc1, Mariana Santo, DO1, Gerardo Diaz Garcia, DO1, Anvit D. Reddy, DO1, Nadim A. Qadir, DO2, Oshin Rai, DO1, Lauren N.. Stemboroski, DO1, Marianny Sulbaran Nava, MD, PhD, MS1 1University of Florida College of Medicine, Jacksonville, FL; 2University of Florida College of Medicine, Windermere, FL
Introduction: Inflammatory bowel disease (IBD), has seen a rising incidence within the pediatric population, with diagnosis most commonly occurring in young adolescence. IBD with onset during childhood has shown a more aggressive disease course compared to adult onset disease. Despite advances in the pharmacologic treatment of IBD, studies show that surgical intervention is often required in the pediatric population. We aim to compare the average age of diagnosis of pediatric Ulcerative Colitis (UC) and Crohn’s Disease (CD) patients that required IBD-related surgery, and furthermore, analyze the time from diagnosis to surgery.
Methods: All pediatric patients with a documented diagnosis of IBD in electronic health records who were seen in either of two different tertiary health care systems from 2012-2023 were screened for major IBD-related surgeries. Patients who underwent major IBD-related surgery prior to turning 19 were chart reviewed, and the age they were diagnosed and underwent initial surgery were compared using unpaired t-test.
Results: In total 31 patients were included, 13 with UC and 18 with CD. In this cohort of patients that required an IBD-related surgical intervention, the disease progression time from diagnosis to surgery was similar between UC and CD (2.2 ± 3.1 and 2.4 ± 2.5, respectively; p=0.92). Patients with UC were significantly younger at age of surgery (p=0.022). Average age of IBD diagnosis was 9.6 ± 3.3 for UC and 12.0 ± 3.9 for CD (p=0.08). Of note, 6 UC patients and 6 CD patients, or 12 of the 31 total patients (38.7%), underwent surgery within one year of diagnosis.
Discussion: Based on our cohort, disease progression of IBD in pediatric patients that require surgical intervention is fast. Patients with Ulcerative colitis may require surgical intervention at a younger age compared to those with Crohn’s Disease. Our findings support that early diagnosis and management are especially vital within pediatric patients given the aggressive course of disease. Further research should investigate the genetic and environmental risk factors that may correlate with early surgical intervention in patients with IBD.
Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
Disclosures:
Landen Shane Burstiner indicated no relevant financial relationships.
Mariana Santo indicated no relevant financial relationships.
Gerardo Diaz Garcia indicated no relevant financial relationships.
Anvit Reddy indicated no relevant financial relationships.
Nadim Qadir indicated no relevant financial relationships.
Oshin Rai indicated no relevant financial relationships.
Lauren Stemboroski indicated no relevant financial relationships.
Marianny Sulbaran Nava indicated no relevant financial relationships.
Landen Shane Burstiner, DO, MSc1, Mariana Santo, DO1, Gerardo Diaz Garcia, DO1, Anvit D. Reddy, DO1, Nadim A. Qadir, DO2, Oshin Rai, DO1, Lauren N.. Stemboroski, DO1, Marianny Sulbaran Nava, MD, PhD, MS1. P1470 - Fast Disease Progression of Inflammatory Bowel Disease in Pediatric Patients That Require Surgery, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
