Raj Mohan Ram Mohan, MD, Sai Reshma Magam, MD, Sai Greeshma Magam, MD, Melvin Joy, MD, Dilman Natt, MD, Winghang Lau, MD, Abhishek Tadikonda, MD, Leeza Pannikodu, MD, Jiten Desai, MD, Krishnaiyer Subramani, MD, Paul Mustacchia, MD, MBA Nassau University Medical Center, East Meadow, NY
Introduction: The impact of race and gender on the development of gastric cancer among patients with gastric intestinal metaplasia (GIM) is a complex and multifaceted issue. While GIM is a precursor to gastric cancer, studies suggest that race and gender may play significant roles in influencing the progression of this condition to malignancy. Understanding the interplay between these factors is essential for developing prevention and intervention strategies to reduce the burden of gastric cancer within diverse populations.
Methods: Our retrospective study (2009-2023) included all patients with Gastric Intestinal Metaplasia (GIM). We gathered data on comorbidities, gastric cancer incidence, gender, race, and socioeconomic factors. To assess the impact of race and gender on gastric cancer rates, we utilized logistic regression to determine their statistical significance and effect size. The association between race and the likelihood of developing gastric cancer was further analyzed using a Chi-square test of independence across different racial groups.
Results: A total of 378 patients diagnosed with gastric intestinal metaplasia were included in the study, of which 72 patients developed gastric cancer in 14 years. 38 (51.3%) patients were female. Among the races 24(33%) Asians, 16(21.6%) Hispanics, 14(19%) Whites, 20 (27.7%) African American. Logistic regression revealed that race has a statistically significant association with the incidence of gastric cancer (p < 0.001), with the odds of gastric cancer increased in Asians (Coefficient:<span style="mso-spacerun: yes;"> </span>0.68, p< 0.05). In contrast, gender did not show a significant impact (p = 0.847). Further examination using a Chi-square test confirmed a significant association between race and gastric cancer (Chi-square = 37.83, p < 0.001).
Discussion: our study underscores the intricate relationship between race and the development of gastric cancer in patients with gastric intestinal metaplasia. The findings reveal a significant association between race, particularly among Asians, and an increased likelihood of gastric cancer. However, gender did not demonstrate a significant impact in our study cohort. These results emphasize the importance of tailored interventions and screenings for at-risk populations, considering the role of race in gastric cancer progression. Further research is needed to delve deeper into the underlying mechanisms of these disparities and to develop more targeted prevention strategies.
Figure: Predicted Probabilities of Gastric Cancer by Race among Patients with Gastric Intestinal Metaplasia (2009-2023)
Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
Disclosures:
Raj Mohan Ram Mohan indicated no relevant financial relationships.
Sai Reshma Magam indicated no relevant financial relationships.
Sai Greeshma Magam indicated no relevant financial relationships.
Melvin Joy indicated no relevant financial relationships.
Dilman Natt indicated no relevant financial relationships.
Winghang Lau indicated no relevant financial relationships.
Abhishek Tadikonda indicated no relevant financial relationships.
Leeza Pannikodu indicated no relevant financial relationships.
Jiten Desai indicated no relevant financial relationships.
Krishnaiyer Subramani indicated no relevant financial relationships.
Paul Mustacchia indicated no relevant financial relationships.
Raj Mohan Ram Mohan, MD, Sai Reshma Magam, MD, Sai Greeshma Magam, MD, Melvin Joy, MD, Dilman Natt, MD, Winghang Lau, MD, Abhishek Tadikonda, MD, Leeza Pannikodu, MD, Jiten Desai, MD, Krishnaiyer Subramani, MD, Paul Mustacchia, MD, MBA. P1607 - Dissecting Diversity: The Role of Race and Gender in Gastric Cancer Risks Among Gastric Intestinal Metaplasia Patients, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
