P4172 - Clinical Characteristics and In-Hospital Mortality in Patients With Gastrointestinal Bleeding and Concomitant Acute Myocardial Infarction: A National Database Analysis From 2016 to 2019

Mahmoud Mahdi, MD¹, Ahmad Mahdi, MD¹, Hasan Jaber, MD², Nader Al Souky, MD¹, Nathan Tofteland, MD¹, William J. Salyers, MD, MPH¹, Hayrettin Okut, PhD¹, Cyrus Munguti, MD^1
1University of Kansas School of Medicine, Wichita, KS; ²University of Kansas Medical Center, Wichita, KS

Introduction: Gastrointestinal bleeding (GIB) in the setting of acute myocardial infarction (AMI) is a complex medical condition that places patients at heightened morbidity and mortality. GIB, especially when massive, can precipitate MI from hypovolemia, myocardial hypoperfusion, and hemodynamic instability. This study aimed to evaluate the rate of in-hospital mortality and length of stay (LOS) in patients with GIB and concomitant AMI and to explore the potential risk factors for this condition.

Methods: A retrospective analysis utilizing the de-identified data from the National Inpatient Sample (NIS) was used to analyze patients hospitalized between 2016 and 2019. We identified patients with GIB and AMI using ICD-9 diagnostic codes. Our search included all patients above the age of 18 with GIB with and without AMI. Univariate and multivariable logistic regression analyses were performed to determine the characteristics, length of stay (LOS), and in-hospital mortality rate of patients with GIB and AMI.

Results: A total of 228,204 patients were identified with GIB as the main diagnosis through data analysis (2016 through 2019). Stratified for AMI, a total of 11,359 patients were obtained. Mortality rate of patients with concomitant AMI and GIB was 9.47% (+/- 0.07%), higher in males (2.82% +/- 0.038%) than females (2.14% +/- 0.03%). The average age of patients on admission was 72.64 years (+/- 28) with an average LOS of 9.7 days. Interestingly, admission rates were higher on weekdays vs weekends (76.4% +/-0.09 vs 23.5% +/- 0.09).

Discussion: Patients admitted with gastrointestinal bleeding (GIB) and concomitant acute myocardial infarction (AMI) face higher in-hospital mortality and longer stays. Early and prompt management of GIB is crucial to prevent complications. Our study highlights the need for high-acuity care and timely treatment of GIB etiologies to reduce mortality and morbidity risks in these patients.


Disclosures:


Mahmoud Mahdi, MD¹, Ahmad Mahdi, MD¹, Hasan Jaber, MD², Nader Al Souky, MD¹, Nathan Tofteland, MD¹, William J. Salyers, MD, MPH¹, Hayrettin Okut, PhD¹, Cyrus Munguti, MD¹. P4172 - Clinical Characteristics and In-Hospital Mortality in Patients With Gastrointestinal Bleeding and Concomitant Acute Myocardial Infarction: A National Database Analysis From 2016 to 2019, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.