Avi Toiv, MD1, Hope Baldwin, BS2, Syed-Mohammed Jafri, MD3 1Henry Ford Hospital, Detroit, MI; 2Wayne State University School of Medicine, Detroit, MI; 3Henry Ford Health, Detroit, MI
Introduction: Researchers are increasingly investigating the possible differences in transplant-related outcomes between men and women. However, few studies have explored whether patient sex is associated with serious outcomes after intestinal transplantation (IT). This study aims to compare visceral transplant outcomes between male and female transplant recipients.
Methods: We conducted a retrospective chart review of all patients who underwent IT or multivisceral transplant (MVT) at an academic transplant center from 2010 to 2023. The primary outcome was patient survival, analyzed with Kaplan-Meier survival analysis.
Results: Among the 50 IT recipients, there were 20 men and 30 women (Table). The median age at transplant was 50 years (range, 22-64). Of the transplants, 58% were exclusively IT, while 42% were MVT. Kaplan-Meier survival analysis (Figure) revealed no significant mortality difference between the groups when analyzed by sex (p=0.28) or when comparing IT alone to MVT (p= >0.05 in all subgroups). Male IT recipients showed a higher need for reoperation within 1 month (p=0.01) but not within 3 months (p=0.44). No significant differences were observed between the sexes in graft failure at 1 or 3 years, moderate-to-severe rejection at 1 or 3 years, or the development of post-transplant chronic kidney disease.
Discussion: Although the literature has highlighted differences in transplant-related outcomes based on patient sex, this study found no significant survival or transplant-related differences between male and female IT and MVT recipients. These findings can help address sex-based disparities in transplant outcomes and inform clinicians as to whether sex is an important consideration for IT evaluations.
Figure: Figure: Kaplan-Meier survival analysis indicate no statistically significant differences in survival times between male and female IT recipients (p=0.28; top analysis), or when comparing IT alone to MVT (p=>0.05 in all subgroups; bottom analysis).
Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
Disclosures:
Avi Toiv indicated no relevant financial relationships.
Hope Baldwin indicated no relevant financial relationships.
Avi Toiv, MD1, Hope Baldwin, BS2, Syed-Mohammed Jafri, MD3. P3192 - Does Sex Matter? A Comparison of Outcomes in Male and Female Intestinal Transplant Recipients, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
