University of Mississippi Medical Center Madison, MS
Yousaf Zafar, MD1, Akash Kumar, 2, Syeda Ilsa Aaqil, 3, Rana Muhammad Umer Nasrullah, 3, Syed Sarmad Javaid, 3, Shahryar Khan, MD4, Laila Manzoor, 1, Arsalan Zafar Iqbal, 1 1University of Mississippi Medical Center, Madison, MS; 2Bilawal Medical College, Jamshoro, Sindh, Pakistan; 3Jinnah Sindh Medical University, Karachi, Sindh, Pakistan; 4University of Kansas, Overland Park, KS
Introduction: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain, bloating, and changes in bowel habits. Increasing evidence suggests effectiveness of the low- FODMAP (fermentable oligo-, di-, and monosaccharides, and polyols) diet in managing IBS symptoms. Therefore, we evaluated the impact of the low FODMAP diet on IBS symptom severity and quality of life (QoL) in IBS patients.
Methods: We conducted a comprehensive search on the PubMed and SCOPUS databases from inception until June 8, 2024, for studies evaluating the effects of low-FODMAP diet on IBS symptom severity assessed by the IBS severity scoring system (IBS-SSS) and QoL assessed by the IBS-QoL questionnaire. The data were represented as mean differences (MD) for these continuous outcomes. Meta-analyses were performed for the quantitative analyses using random-effects models with inverse variance weighing.
Results: Our meta-analysis included fifteen studies with total of 1198 participants. The pooled analysis demonstrated that patients on low-FODMAP diet experienced decrease in IBS-SSS compared to those on control diet (MD -49.91; 95% CI -76.94, -22.89; I2 = 89%, Figure 1a). Additionally, low-FODMAP diet significantly improved IBS-QoL scores compared to a control diet (MD 5.51; 95% CI 3.16, 7.85; I2 = 32%, Figure 1b).
Discussion: The low-FODMAP diet reduces IBS symptom severity and enhances QoL in individuals with IBS. These findings underscore the potential of the low-FODMAP diet as an effective treatment for managing IBS symptoms.
Figure: Figure 1a) Effect of low-FODMAP diet on IBS-SSS in patients with IBS Figure 1b) Effect of low-FODMAP diet on QoL values in patients with IBS
Disclosures:
Yousaf Zafar indicated no relevant financial relationships.
Akash Kumar indicated no relevant financial relationships.
Syeda Ilsa Aaqil indicated no relevant financial relationships.
Rana Muhammad Umer Nasrullah indicated no relevant financial relationships.
Syed Sarmad Javaid indicated no relevant financial relationships.
Shahryar Khan indicated no relevant financial relationships.
Laila Manzoor indicated no relevant financial relationships.
Arsalan Zafar Iqbal indicated no relevant financial relationships.
Yousaf Zafar, MD1, Akash Kumar, 2, Syeda Ilsa Aaqil, 3, Rana Muhammad Umer Nasrullah, 3, Syed Sarmad Javaid, 3, Shahryar Khan, MD4, Laila Manzoor, 1, Arsalan Zafar Iqbal, 1. P3209 - The Impact of Low-FODMAP Diet in Managing Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
