P3320 - Temporal Trends in the Incidence of Peptic Ulcer Disease in Canada Over the Past 3 Decades

Ahmed A. Abdulelah, MD¹, Lina AlQirem, MD², Zaid A. Abdulelah, MD³, Mohammad Alqaisieh, MD⁴, Yazan Gharaibeh, MD⁵, Abdel-Rahman Al Husni, MD⁶, Amer Khatib, MD^6
1University of Edinburgh, Edinburgh, Scotland, United Kingdom; ²University of Arkansas for Medical Sciences, Little Rock, AR; ³Royal Papworth Hospital, Cambridge, England, United Kingdom; ⁴Hamilton Medical Center, Dalton, GA; ⁵Royal Free London NHS Trust, London, England, United Kingdom; ⁶University of Jordan, Amman, 'Amman, Jordan

Introduction: Peptic ulcer disease (PUD) is among the most prevalent gastrointestinal diseases worldwide with considerable variation in incidence among regions and nations. Additionally, PUD results in considerable global health burden due to the resultant morbidity and diminished quality of life. Accordingly, the identification of temporal trends in the incidence of PUD is of paramount significance in the introduction of effective interventions, both preventative and therapeutic, and healthcare policies.

Methods: The incidence of PUD in Canada over the past 30 years was initially evaluated by retrieving the relevant data from the Global Burden of Diseases 2019 database. The temporal trends in the incidence were evaluated through the use of Joinpoint Regression Analysis software that was utilized to calculate the Annual Percentage Change (APC) and Average Annual Percentage Change (AAPC) stratified by gender and age.

Results: Over the period 1990-2019, a total of 452,089 PUD cases were reported in Canada with a female predominance of 54.1%. Stratification by age revealed a statistically significant decline in PUD incidence, with the most prominent decline being reported in individuals aged 75 years and older with an AAPC of -2.96 (95%CI -3.00 to -2.92; p< 0.001). A similar, but slightly less, decrease in PUD incidence was observed in the 50-74 years old age group with an AAPC of -2.63 (95%CI -2.66 to -2.60; p< 0.001). Younger individuals also observed a decline, but smaller, in the incidence of PUD with an AAPC of -0.28 (95%CI -0.30 to -0.26; p< 0.001). Upon stratification by gender, statistically significant decrements in PUD incidence were noted in both males and females, with males having an AAPC of -1.02 (95%CI -1.04 to -1.00; p< 0.001) while females had an AAPC of -0.88 (95%CI -0.90 to -0.86; p< 0.001).

Discussion: Over the span of 3 decades, the incidence of PUD in Canada witnessed a significant decline across all age groups and in both males and females. These findings in Canada are consistent with other developed nations due to improved hygienic practices, and cautious use of NSAIDs.


Disclosures:


Ahmed A. Abdulelah, MD¹, Lina AlQirem, MD², Zaid A. Abdulelah, MD³, Mohammad Alqaisieh, MD⁴, Yazan Gharaibeh, MD⁵, Abdel-Rahman Al Husni, MD⁶, Amer Khatib, MD⁶. P3320 - Temporal Trends in the Incidence of Peptic Ulcer Disease in Canada Over the Past 3 Decades, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.