P3330 - Trends in Mortality Due to Disorders of Peptic Ulcer Among Patients Aged 55 and Older in the United States: Insights from the CDC WONDER Database

Ammad Javaid. Chaudhary, MD¹, Momin Samad, MD², Muhammad Z. Khan, MD¹, Muhammad Naveed, MBBS³, Bazil Azeem, MBBS⁴, Rabia Iqbal, MBBS³, Ahila Ali, MBBS³, Muhammad Omer Rehan, MBBS³, Tazheen Mohammad, MBBS⁵, Huzaifa Ansari, MBBS⁶, Fnu Muhibullah, MD, MBBS^7
1Henry Ford Health, Detroit, MI; ²Henry Ford Hospital, Rochester Hills, MI; ³Dow Medical College, Karachi, Sindh, Pakistan; ⁴Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, Sindh, Pakistan; ⁵Dow, Detroit, MI; ⁶Dow University of Health Sciences, Karachi, Sindh, Pakistan; ⁷West Virginia University Camden Clark Medical Center, Parkersburg, WV

Introduction: Peptic ulcer disease remains a significant cause of morbidity and mortality among older adults. This study aims to analyze trends and demographic disparities in mortality due to peptic ulcers among patients aged 55 and older in the United States from 1999 to 2020.

Methods: Utilizing data from the CDC WONDER database, a retrospective analysis was conducted to determine age-adjusted mortality rates (AAMRs) per 100,000 persons. Trends were assessed using Average Annual Percentage Change (AAPC) and Annual Percent Change (APC), stratified by year, sex, race/ethnicity, and geographical regions.

Results: Between 1999 and 2020, peptic ulcers caused 150,717 deaths among adults aged 55 and older in the U.S., mostly in medical facilities (66.3%). The overall AAMR decreased significantly from 18.4 in 1999 to 7.7 in 2020, with an AAPC of -4.60 (95% CI: -5.0 to -4.23, p < 0.000001). Notably, a sharp decline was seen from 1999 to 2009 (APC: -8.53, p < 0.000001), followed by a slower decrease from 2009 to 2020 (APC: -0.86, p = 0.129). Men had slightly higher AAMRs than women (men: 11.3; women: 8.1), with both experiencing decreased rates (men: AAPC: -4.76, p < 0.000001; women: AAPC: -4.16, p < 0.000001). Racially, Whites had the highest AAMR (9.6), followed by Black or African Americans (9.4), Asian or Pacific Islanders (8.9), American Indian or Alaska Natives (8.8), and Hispanic or Latino populations (7.1). All racial groups saw significant declines in AAMRs from 1999 to 2020, with the most substantial decrease in Asian individuals (AAPC: -5.51, p < 0.000001).Geographically, AAMRs varied by state, highest in Vermont (AAMR: 13.6) and lowest in Massachusetts (AAMR: 6.7). The Western region had the highest average AAMR (11.7). Nonmetropolitan areas had slightly higher AAMRs than metropolitan areas throughout, both seeing significant decreases from 1999 to 2020.

Discussion: This study reveals significant declines in mortality rates due to peptic ulcers among older adults in the United States from 1999 to 2020. However, demographic disparities persist, underscoring the need for targeted interventions and equitable healthcare access to further reduce mortality and improve health outcomes in affected populations. Further research is warranted to explore underlying factors contributing to these disparities and to inform effective public health strategies.



Disclosures:


Ammad Javaid. Chaudhary, MD¹, Momin Samad, MD², Muhammad Z. Khan, MD¹, Muhammad Naveed, MBBS³, Bazil Azeem, MBBS⁴, Rabia Iqbal, MBBS³, Ahila Ali, MBBS³, Muhammad Omer Rehan, MBBS³, Tazheen Mohammad, MBBS⁵, Huzaifa Ansari, MBBS⁶, Fnu Muhibullah, MD, MBBS⁷. P3330 - Trends in Mortality Due to Disorders of Peptic Ulcer Among Patients Aged 55 and Older in the United States: Insights from the CDC WONDER Database, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.