P3440 - Associated Factors With Malignancy in Pancreatic Neoplasms in a Population From Northeastern Colombia

Johan Ricardo. Gonzalez Rodriguez, MD¹, German Manuel Tovar Fierro, ², Edgar Julian. Ferreira Bohorquez, MD², Miguel Enrique. Ochoa Vera, ¹, Maria L. Luna-Gonzalez, ¹, Juan Martin. Betancur Calderon, ¹, Diana Carolina Ospina Galeano, ³, Diana Liseth. Galan Borda, MS^4
1Universidad Autonoma de Bucaramanga, Bucaramanga, Santander, Colombia; ²Fundacion Oftalmologica de Santander FOSCAL, Bucaramanga, Santander, Colombia; ³Universidad Autónoma de Bucaramanga, Bucaramanga, Santander, Colombia; ⁴Universidad Santo Tomas, Bucaramanga, Santander, Colombia

Introduction: Pancreatic cancer ranks seventh in global mortality, with a death rate exceeding 70% in Colombia. It is the most common gastrointestinal tumor outside the digestive tract and is considered highly aggressive due to its asymptomatic presentation and late diagnosis. While global screening guidelines have been established to identify familial factors and individuals with genetic susceptibility, it is crucial to recognize non-modifiable factors that may suggest new screening modalities in the population, impacting early diagnosis and cancer mortality. Therefore, the aim of this study was to establish factors associated with malignancy in pancreatic masses among patients at a level IV institution in Colombia.

Methods: This was a cross-sectional study with secondary analysis of an anonymized database of patients diagnosed with de novo pancreatic mass through endoscopic ultrasound at the Fundación Oftalmológica de Santander (FOSCAL) between July 2018 and June 2023. Sociodemographic, familial, clinical, histopathological, and endosonographic characteristics of patients were analyzed concerning pancreatic mass malignancy, and prevalence ratios were calculated as a measure of association.

Results: Out of 136 cases analyzed, the median age at diagnosis was 68 years, 57.85% were female, diabetes was the most common comorbidity (36.03%), and only 5.15% of patients had a family history of pancreatic cancer. 77.2% were malignant tumors of any kind, with 71.3% classified as pancreatic cancer. Regarding the prevalence of pancreatic cancer, a higher association was found for diabetes (PR: 1.3; P=0.013), alcohol consumption (PR: 1.33; P=0.026), mass > 3 cm (PR: 1.49; P=0.012), jaundice (PR: 1.53; P< 0.001), and weight loss (PR: 1.53; P< 0.001).

Discussion: The prevalence of pancreatic cancer in patients without genetic susceptibility in the northeastern region of Colombia was high, indicating the need for future research focused on screening in this area. Prioritizing patients with a history of diabetes and alcohol consumption, as well as those presenting with jaundice and weight loss, could facilitate early diagnosis and timely treatment as a curative option


Disclosures:


Johan Ricardo. Gonzalez Rodriguez, MD¹, German Manuel Tovar Fierro, ², Edgar Julian. Ferreira Bohorquez, MD², Miguel Enrique. Ochoa Vera, ¹, Maria L. Luna-Gonzalez, ¹, Juan Martin. Betancur Calderon, ¹, Diana Carolina Ospina Galeano, ³, Diana Liseth. Galan Borda, MS⁴. P3440 - Associated Factors With Malignancy in Pancreatic Neoplasms in a Population From Northeastern Colombia, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.