Mohamad Sharbatji, MD1, Abhishek Ravinuthala, MD2, Hasan Raza, MD2, Heba Aziza, MD1, Nihal Khan, MD1, Saeed Ali, MD1, Sarfraz Ahmad, PhD1 1AdventHealth, Orlando, FL; 2University of Chicago Medical Center, Chicago, IL
Introduction: Gallstone disease is a costly and common digestive disease in the Western countries, and the prevalence in adults is rising annually. It is common in patients that undergo bariatric surgery. In this study we aim to assess the impact of obesity and bariatric surgery on the outcomes for gallstone disease hospitalizations in the United States.
Methods: The National Inpatient Sample for the years 2019 and 2020 was used to capture gallstone disease hospitalizations. Selected population comprised of three cohorts: A, B, and C based on obesity and bariatric surgery status.
Results: There were 150,000 (71.3%) hospitalizations in Cohort-A, 54,000 (25.7%) in Cohort-B and 6,365 (3%) in Cohort-C with principal diagnosis of gallstone disease. Both Cohort-B [adjusted odds ratio (aOR) 1.96; 95% confidence interval (CI), 1.9-2.0)] and Cohort-C (aOR 2.8; 95% CI, 2.67-3.0) were more frequently admitted with gallstone disease as compared to Cohot-A. Chances of developing in-hospital complications as acute kidney injury (AKI), acute pancreatitis (AP), or acute cholangitis (AC) were higher among Cohort-B (aOR 1.2; 95% CI, 1.1-1.3) and Cohort-C (aOR 1.2; 95% CI, 1.01-1.4) as compared to Cohort-A. Chances of in-hospital deterioration and requiring escalation of care to intensive care for managing acute hypoxic respiratory failure, hypotension, or altered mental status were higher among Cohort-B (aOR 1.1; 95% CI, 1.01-1.2), and similar among Cohort-C (aOR 1.1; 95% CI, 0.8-1.4) as compared to Cohort-A. All-causes in-patient mortality was similar for Cohort-B (aOR 0.65; 95% CI, 0.4-1.05) as compared to Cohort-A.
Discussion: Obesity and bariatric surgery increase the risk of hospitalization with gallstone disease. Obesity does not increase all-cause inpatient mortality compared to normal weight hospitalization. AKI, AP, and AC were more likely encountered among obese and bariatric patients admitted with gallstone disease.
Figure: Odds ratio for major outcomes of Cohort B as compared to Cohort A gallstone disease hospitalization for the years 2019 and 2020 combined
Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
Disclosures:
Mohamad Sharbatji indicated no relevant financial relationships.
Abhishek Ravinuthala indicated no relevant financial relationships.
Hasan Raza indicated no relevant financial relationships.
Heba Aziza indicated no relevant financial relationships.
Nihal Khan indicated no relevant financial relationships.
Saeed Ali indicated no relevant financial relationships.
Sarfraz Ahmad indicated no relevant financial relationships.
Mohamad Sharbatji, MD1, Abhishek Ravinuthala, MD2, Hasan Raza, MD2, Heba Aziza, MD1, Nihal Khan, MD1, Saeed Ali, MD1, Sarfraz Ahmad, PhD1. P3476 - Impact of Bariatric Surgery and Obesity on Hospitalized Patients With Gallstone Disease: A National Inpatient Sample Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
