P3630 - Early Onset GI Malignancies in Women: A SEER Database Analysis

Sheena Bhushan, MD¹, Abijha Boban, DO, MBA², Lisa Gambini, MPH², Nikki Nikzad, MS³, Oluseyi Abidoye, MD^4
1Northeast Georgia Medical Center, Buford, GA; ²Northeast Georgia Medical Center, Atlanta, GA; ³Velocity Clinical, Seattle, WA; ⁴Mayo Clinic, Phoenix, AZ

Introduction: Although early onset GI cancers in women under 50 years of age has been on the rise. However, there are limited studies evaluating this shift in epidemiology. The aim of this study was to examine the prevalence and survival trends of various GI malignancies in women under 50 years of age in the United States.

Methods: Data were collected from SEER research plus database containing 17 registries. from years 2000-2021. Females between 15-49 years of age and histology confirmed GI malignancies were included. Data on variables including survival months, race, median household income, were also included. Analysis was done using descriptive statistics and Chi square tests. Kaplan- Meir Survival analysis and Cox regression analysis.

Results: Of the total 6,198 women diagnosed with early onset GI malignancies, majority of were white 69.6% (n=4,311) followed by Asian or Pacific Islander 14.4% (n=893), African American 14.2% (n=883) and American Indian/Alaska Native 1.8% (n=111). Colorectal cancer 56% (n=3,472) was the most prevalent GI malignancy, followed by appendiceal cancer 11.8% (n=731), and gastric cancer 9.3% (n=578). The least common were gallbladder in 1.1% (n=69), biliary in 1% (n=63) and esophageal cancer in 1% (n=61). The most common age group affected was between 45-49 years 40.1% (n=2486), with decreasing frequency in the younger age groups. With regard to survival, appendiceal cancer had the longest estimated mean survival time (M=67.35 months), while gallbladder cancer had the shortest (M=27.89 months). The Breslow (Generalized Wilcoxon) test showed significant differences in survival distributions among the malignancy types, χ²(10) = 570.529, p < .001 (Image 1), among racial groups (χ²(3) = 8.908, p = .031) and age groups (χ²(6) = 30.685, p < .001).Compared to White women, Black women had a marginally non-significant lower risk of mortality (B = -0.294, SE = 0.181, p = .105, Exp(B) = 0.745, 95% CI [0.522, 1.063]). Compared to the youngest age group (15-19), the risk of mortality increased with age; women aged 35-39 had a significantly higher risk (B = 1.161, SE = 0.455, p = .011, Adj OR = 3.192, 95% CI [1.309, 7.781]), and those aged 40-44 had an even higher risk (B = 1.206, SE = 0.454, p = .008, Adj OR = 3.340, 95% CI [1.373, 8.124]).

Discussion: High clinical suspicion and personalized approaches to cancer screening on risk factors may aid in early detection and treatments in this age group.


Disclosures:


Sheena Bhushan, MD¹, Abijha Boban, DO, MBA², Lisa Gambini, MPH², Nikki Nikzad, MS³, Oluseyi Abidoye, MD⁴. P3630 - Early Onset GI Malignancies in Women: A SEER Database Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.