P3654 - Disparities in Colorectal Cancer Mortality Among Individuals with Chronic Kidney Disease in the United States: A CDC WONDER Database Analysis

M Danial Ali Shah, MD¹, Stephanie Ibarra, MD², Zarak H. Khan, MD^2
1King Edward Medical University, Lahore, Punjab, Pakistan; ²East Carolina University, Greenville, NC

Introduction: Chronic kidney disease (CKD) can limit treatment options and worsen outcomes in colorectal cancer (CRC). This study aims to identify disparities and trends in mortality among CKD patients to inform future healthcare strategies and enhance evidence-based interventions for this demographic.

Methods: We conducted a retrospective analysis of the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database using ICD-10 codes (C18, C19, N18) to identify deaths from CRC in CKD patients aged 35 and older from 1999 to 2020. Mortality rates were analyzed by age, gender, race, region, rural/urban classification, and place of death, reported as age-adjusted mortality rates (AAMR) with 95% confidence intervals (CI). Trends over time were identified using joinpoint regression and reported as an average annual percentage change (AAPC).

Results: A total of 16,818 deaths were reported from 1999 to 2020 in CKD patients due to CRC, with an AAMR of 0.5 per 100,000 (95% CI: 0.5-0.5). The AAMR increased from 0.3 in 1999 to 0.5 in 2020 (AAPC 2.19; 95% CI: 0.68-4.14). Males exhibited a higher AAMR than females (0.7 vs. 0.3), and non-Hispanics had a higher AAMR than Hispanics (0.5 vs. 0.4). Blacks had double the AAMR of Whites (0.9 vs. 0.4). The West and Midwest were the most affected regions, both with an AAMR of 0.5. State variations were highest in North Dakota and the District of Columbia (0.9 and 0.8), and lowest in Idaho and Arizona (0.3 and 0.2). Rural areas had a higher AAMR than urban areas (0.5 vs. 0.4). Most deaths occurred in inpatient settings (38%), with the ≥75-year age group accounting for the majority (67.3%).

Discussion: Mortality related to CRC is steadily rising among CKD patients across all genders and racial groups. Further research is essential to understand the underlying factors and help develop effective preventive strategies.



Disclosures:


M Danial Ali Shah, MD¹, Stephanie Ibarra, MD², Zarak H. Khan, MD². P3654 - Disparities in Colorectal Cancer Mortality Among Individuals with Chronic Kidney Disease in the United States: A CDC WONDER Database Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.