P3835 - African American Patients Taking GLP-1RA are More Likely to Have Poor Bowel Prep: A Single Center Study

Noor Hassan, MD¹, Mohamed Ahmed, MD², Mir Zulqarnain, DO³, Misha Gautam, MD¹, Ameen Awad, MD³, Sruthi Sripada, BA³, Abbas Bader, BA³, Samiya Azim, BA³, Mohamed Refaat, BA⁴, Mirdhula Ananthamurugan, BA³, Ifrah Fatima, MD³, Islam Mohamed, MD⁵, Esmat Sadeddin, MD³, Tahar M. Mahmoudi, MD³, Hassan Ghoz, MD^3
1University of Missouri Kansas City School of Medicine, Kansas City, MO; ²University of Missouri-Kansas City, Saint Luke's Hospital, Kansas City, MO; ³University of Missouri - Kansas City School of Medicine, Kansas City, MO; ⁴University of Missouri, Kansas City, MO; ⁵University of Missouri, Columbia, MO

Introduction: The Boston Bowel Preparation Scale (BPPS) is a widely recognized tool used to assess the quality of bowel preparation prior to colonoscopy. Inadequate prep can compromise the accuracy of diagnosis and impede on therapeutic capabilities for endoscopists. Glucagon-like peptide 1 receptor agonists (GLP-1RA) have become a very popular class of medications for the management of diabetes and obesity but have a known side effect of slowing gastric motility. Studies have shown decreased bowel preparation quality with GLP-1RA usage, however these studies predominantly involved White patients. The purpose of our research was to determine the effect of GLP-1RA on bowel preparation in a diverse patient population, with a particular focus on African American patients.

Methods: This retrospective study was conducted in a single tertiary medical center in Kansas City, Missouri. A comprehensive analysis was conducted using data from October 2015 – March 2019. We included all patients taking GLP-1RA for diabetes or obesity at the time of colonoscopy. Patients who underwent colonoscopy in the inpatient setting were excluded to avoid external factors which may affect bowel preparation. Correlation of the effect of GLP-1RA on bowel prep was assessed using odds ratio with a 95% CI.

Results: A total of 198 patients were identified from our hospital database. The first group consisted of 115 patients who were White (58.1%) while the second group included 83 African American patients (41.9%). The mean age of the first group was 62.6 as compared to 61.1 for the second group. The mean BMI of the first group was 38.2 compared to 39.7 for the second group. 55.6% of the White group were females as compared to 83.1% in the African American group. The first group had 67% BBPS score of < 5 as compared to 81.9%. The African American population had an OR of 2.23 (95% CI 1.13-4.42) of having a BBPS score of < 5.

Discussion: This study highlights a significant association between GLP-1RA and the quality of bowel preparation as assessed by BPPS. Our findings indicate that patients on GLP-1RA are more likely to have inadequate bowel preparation with BPPS < 5. Specifically, the African American population demonstrated a higher odds ratio for inadequate bowel prep, indicating a potential need for tailored preparation strategies in this group. Overall, our study underscores the importance of considering GLP-1RA use and patient demographics when planning for colonoscopy preparation to ensure optimal outcomes.


Disclosures:


Noor Hassan, MD¹, Mohamed Ahmed, MD², Mir Zulqarnain, DO³, Misha Gautam, MD¹, Ameen Awad, MD³, Sruthi Sripada, BA³, Abbas Bader, BA³, Samiya Azim, BA³, Mohamed Refaat, BA⁴, Mirdhula Ananthamurugan, BA³, Ifrah Fatima, MD³, Islam Mohamed, MD⁵, Esmat Sadeddin, MD³, Tahar M. Mahmoudi, MD³, Hassan Ghoz, MD³. P3835 - African American Patients Taking GLP-1RA are More Likely to Have Poor Bowel Prep: A Single Center Study, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.