P3434 - Relationship Between Idiopathic Pancreatitis and Inflammatory Bowel Disease: A Nationwide Analysis From a United States Large Database

Alejandro J. Nieto Dominguez, MD, Sarah Eichinger, DO, Chun-Wei Pan, MD, Abhin Sapkota, MD, Muhammad Tayyab Anwar, MD, Patricia Zarza, MD
John H. Stroger, Jr. Hospital of Cook County, Chicago, IL

Introduction: Pancreatitis is a common gastrointestinal condition related to a wide variety of causes including gallbladder stones, hypertriglyceridemia and alcohol abuse. When there is no clear etiology, the term idiopathic acute pancreatitis (IAP) is used. Some studies have shown an association between acute pancreatitis and inflammatory bowel disease (IBD). IBD (including ulcerative colitis (UC) and Crohn’s disease (CD)) is associated with multiple gastrointestinal and extraintestinal complications and has been demonstrated to be associated with biliary and drug induced etiologies of acute pancreatitis. This study aims to examine the association of acute pancreatitis including IAP and biliary pancreatitis in patients with IBD.

Methods: Our study utilized data from the National Inpatient Sample, a comprehensive U.S. database of inpatient hospital stays, from 2016 to 2019. We focused on patients admitted with acute pancreatitis due to several etiologies (biliary and idiopathic). The aim was to analyze various patient characteristics and understand how they relate to the presence of inflammatory bowel disease. For our statistical analysis, we used STATA version 18.

Results: For UC, there was a significant positive association with IAP with odds ratio (OR): 2.08 (95% CI: 1.59 to 2.74, P< 0.01), In the case of CD, the association was also significant with OR: 1.77 (95% CI: 1.42 to 2.21, P< 0.01). For UC, there was no significant association with biliary pancreatitis (OR: 0.938, 95% CI: 0.773 to 1.138, P=0.517). Similarly, CD showed no significant association with biliary pancreatitis (OR: 0.983, 95% CI: 0.848 to 1.141, P=0.826).

280 patients studied had a diagnosis of IAP and UC. Average age was 47 years old, with a predominance of females (55.36%). 69.64% were White, 12.50% Black, 3.57% Hispanic, and 14.29% Asian or Pacific Islander. In patients with CD, 410 had IAP. Mean age was 48 years old, with a female majority of 58.54%. 81.71% White, 13.41% Black, 1.22% Hispanic, and 3.66% Asian or Pacific Islander.

Discussion: There was a significant positive association between IAP in patients with underlying IBD. Previous studies have shown the presence of acute idiopathic pancreatitis in patients with IBD can be used as a prognostic factor for a higher risk of a more aggressive disease. Further studies are needed to identify triggers and therapeutic strategies for IAP in this special population.


Disclosures:


Alejandro J. Nieto Dominguez, MD, Sarah Eichinger, DO, Chun-Wei Pan, MD, Abhin Sapkota, MD, Muhammad Tayyab Anwar, MD, Patricia Zarza, MD. P3434 - Relationship Between Idiopathic Pancreatitis and Inflammatory Bowel Disease: A Nationwide Analysis From a United States Large Database, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.