P2862 - The Relationship Between Fibrosis Score and Age on Mortality in Hepatocellular Carcinoma Patients Over the Past Decade

Vignesh Krishnan Nagesh, MBBS¹, Ayrton Bangolo, MBBS¹, Vivek Joseph Varughese, MBBS², Bilal Niazi, MD³, Chinmay Trivedi, MBBS¹, Gomathy A. Nageswaran, MBBS⁴, Aiswarya Menon, MBBS¹, Imranjot Singh Sekhon, MBBS¹, Aman Siddiqui, MBBS⁵, Shraboni Dey, MBBS¹, Adam Atoot, MD¹, John Sotiriadis, MD, PhD, FACG¹, Pierre Fwelo, MPH^6
1Hackensack Meridian Palisades Medical Center, North Bergen, NJ; ²Prisma Health, University of South Carolina School of Medicine, Columbia, SC; ³University of Nebraska Medical Center, Omaha, NE; ⁴University of Arkansas for Medical Sciences, Little Rock, AR; ⁵Hackensack Meridian Health - Palisades Medical Center, North Bergen, NJ; ⁶UT Health, Houston, TX

Introduction: Hepatocellular Carcinoma (HCC) is a significant health concern with varied demographic and clinicopathologic characteristics influencing patient outcomes. HCC has traditionally been linked to cirrhosis, but recently, cases have also emerged among patients with mild to moderate fibrosis. However, limited data exists on how the degree of fibrosis impacts HCC mortality, particularly when considering its interaction with other independent prognostic factors. This study investigates the factors associated with all-cause and cancer-specific mortality among US patients diagnosed with HCC between 2010 and 2021, with a specific focus on the interaction between fibrosis score and age.

Methods: 15,796 US patients diagnosed with HCC, between 2010 and 2021, were enrolled in our study by retrieving data from the Surveillance, Epidemiology, and End Results (SEER) database. We analyzed demographics, clinical characteristics, and overall mortality (OM) as well as cancer-specific mortality (CSM) of HCC. Variables with a p-value < 0.1 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors, with a hazard ratio (HR) of greater than 1 representing adverse prognostic factors. Furthermore, we analyzed the effect of the interaction between age and fibrosis score on mortality.

Results: The patient cohort was predominantly male (77.23%), with the majority diagnosed between ages 60-79 (59.62%). Most cases were localized at diagnosis (61.02%), with a significant proportion of patients having cirrhosis (81.74%) and residing in large metropolitan areas (62.95%). Crude analysis revealed that males, older age groups, unmarried status, advanced tumor stages, lower income, and cirrhosis were associated with higher mortality. Multivariate analysis confirmed that males, older age, unmarried status, advanced tumor stages, and cirrhosis increased mortality risk, while chemotherapy and surgery significantly reduced it. Interaction analysis indicated that older patients with cirrhosis exhibited reduced risks, particularly in those aged 80+.

Discussion: This study highlights critical factors influencing mortality among HCC patients, emphasizing the importance of early diagnosis, marital support, and effective treatment strategies. The interaction between age and fibrosis underscores the need for tailored management approaches based on patient age and fibrosis status to improve survival outcomes.


Disclosures:


Vignesh Krishnan Nagesh, MBBS¹, Ayrton Bangolo, MBBS¹, Vivek Joseph Varughese, MBBS², Bilal Niazi, MD³, Chinmay Trivedi, MBBS¹, Gomathy A. Nageswaran, MBBS⁴, Aiswarya Menon, MBBS¹, Imranjot Singh Sekhon, MBBS¹, Aman Siddiqui, MBBS⁵, Shraboni Dey, MBBS¹, Adam Atoot, MD¹, John Sotiriadis, MD, PhD, FACG¹, Pierre Fwelo, MPH⁶. P2862 - The Relationship Between Fibrosis Score and Age on Mortality in Hepatocellular Carcinoma Patients Over the Past Decade, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.