P2578 - Exploring Gastrointestinal Symptoms and Inflammatory Bowel Disease in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder

Tarek Odah, MD¹, Dacre Knight, MD¹, Fairweather DeLisa, PhD¹, Shilpa Gajarawala, ¹, Katelyn Bruno, PhD², Francis A. Farraye, MD, MSc^1
1Mayo Clinic, Jacksonville, FL; ²University of Florida, Gainesville, FL

Introduction: Hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are among a group of inherited conditions marked by joint hypermobility and musculoskeletal complications. Limited data exists on their association with gastrointestinal symptoms and diseases, including inflammatory bowel disease. Our study aims to assess this connection.

Methods: This study is a retrospective analysis based on an intake questionnaire from the Mayo Clinic Florida Ehlers-Danlos syndrome (EDS) clinic, involving patients diagnosed with hEDS and HSD. Patient data obtained from the questionnaire was self-reported and collected from October 2019 to January 2024. Patients seen in the EDS Clinic received a diagnosis of hEDS or HSD according to the 2017 diagnostic criteria; patients seen in the EDS Clinic but not diagnosed with hEDS or HSD were classified as control patients. Patients under 18 years of age were excluded. Logistic regression was used for analysis.

Results: A total of 1,551 adult patients were included in the analysis, comprising 353 with hEDS and 1,198 with HSD, compared to 399 control patients. The average age was 34.6 years ±11.9, with 92.8% female participants and 94.7% identifying as White. Table 1 presents the percentages and odds ratios of various gastrointestinal symptoms and diseases. Compared to controls, the odds ratios for gastrointestinal (GI) symptoms were 1.6 [CI 1.1-2.3, p < 0.01] in the hEDS cohort, 1.46 [CI 1.1-1.9, p < 0.01] in the HSD cohort, and 1.49 [CI 1.1-1.9, p < 0.01] overall. The odds of having irritable bowel syndrome (IBS) was 1.08 [CI 0.8-1.5, p=0.63] for hEDS and 1.17 [CI 0.9-1.5, p=0.18] for HSD. In the hEDS cohort, compared to controls, the odds ratios for Crohn's disease (CD) were 2.3 [CI 0.6-9.2, p=0.25] and for ulcerative colitis (UC) were 0.56 [CI 0.2-1.7, p=0.29], while in the HSD cohort, the odds ratios for CD were 1.22 [CI 0.3-4.4, p=0.76] and for UC were 0.56 [CI 0.3-1.2, p=0.15].

Discussion: Our analysis indicates a significant association between self-reported GI symptoms and both hEDS and HSD. While there was a positive but non-significant association of hEDS/HSD with both CD and IBS, and a negative non-significant association between hEDS/HSD and UC, the small number of patients with UC and CD makes interpretation difficult. Additional studies with larger numbers of participants are needed to evaluate these possible associations.


Disclosures:


Tarek Odah, MD¹, Dacre Knight, MD¹, Fairweather DeLisa, PhD¹, Shilpa Gajarawala, ¹, Katelyn Bruno, PhD², Francis A. Farraye, MD, MSc¹. P2578 - Exploring Gastrointestinal Symptoms and Inflammatory Bowel Disease in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.