P2587 - Extraintestinal Manifestations of Inflammatory Bowel Disease at a Jamaican Teaching Hospital: A Cross-Sectional Study

Kerry-Ann T. Penn-Brown, MBBS, DM¹, Natalie Guthrie- Dixon, MSc², Michael Lee, MBBS, DM, FACG¹, Yvonne Dawkins, MBBS, DM, FACG^1
1University of the West Indies, Kingston, Kingston, Jamaica; ²Caribbean Institute for Health Research, Kingston, Kingston, Jamaica

Introduction: Inflammatory Bowel Disease (IBD) is characterized by a chronic relapsing inflammatory disorder within the gastrointestinal tract (GI). Crohn’s Disease (CD) and Ulcerative Colitis (UC) are the 2 major forms. It is also associated with extraintestinal manifestations (EIM) which may affect varying organ systems. The aim of this study was to determine the frequency and explore the association of major EIMs with various sociodemographic and clinical features in IBD patients at a Jamaican teaching hospital.

Methods: This was a cross-sectional study of patients 16 years and older, with a diagnosis of IBD, managed at the University Hospital of the West Indies between January 2012 and December 2022. Patterns of each major EIM (musculoskeletal, mucocutaneous, ocular, hepatobiliary or renal) amongst patients with CD and UC were ascertained using frequency distributions and prevalence estimates. Means and standard deviations were used to summarize level of disease activity and differences determined using Mann-Whitney tests. Preliminary associations of sociodemographic and clinical factors with EIM prevalence were determined using Pearson’s chi-squared tests which informed the model building process. Multivariable logistic regression models were used to compare the odds of having any major EIM based on IBD type, after controlling for sex, family history of IBD, smoking, disease duration and current treatment for IBD. All final analyses used p< 0.05 as the threshold for statistical significance.

Results: Data for 125 patients were analysed and approximately 40% had at least one EIM. The prevalence of any EIM among patients with UC was 40.8% (95% CI: [29.4%, 52.3%]) and 35.2% (95% CI: [22.4%, 47.9%]) among patients with CD. The most common EIM for patients with UC was musculoskeletal 18.3% (95%CI: [9.3%, 27.3%]) and mucocutaneous among patients with CD 16.7% (95% CI: [6.7%, 26.6%]). Of patients with CD, compared to those without mucocutaneous EIM, a greater proportion of those with mucocutaneous EIM had colonic disease (66.7% versus 18.2%; p< 0.001) and compared to those without musculoskeletal EIM, those with musculoskeletal EIM had higher disease activity at the time of EIM diagnosis (Mean Harvey Bradshaw Index 4.6 versus 2.1; p=0.017).

Discussion: EIMs affect approximately 40% of Jamaican IBD patients. Colonic disease status and higher disease activity at time of diagnosis were significantly associated with presence of mucocutaneous and musculoskeletal EIMs in CD respectively.


Disclosures:


Kerry-Ann T. Penn-Brown, MBBS, DM¹, Natalie Guthrie- Dixon, MSc², Michael Lee, MBBS, DM, FACG¹, Yvonne Dawkins, MBBS, DM, FACG¹. P2587 - Extraintestinal Manifestations of Inflammatory Bowel Disease at a Jamaican Teaching Hospital: A Cross-Sectional Study, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.