P2449 - A Two-Decade Analysis of Peptic Ulcer Mortality in the U.S (1999-2020)

Muhammad Sohaib Khan, ¹, Mohammad Danish, MBBS², Muzamil Khan, MBBS³, Umar Mahmood, MBBS², Muhammad Jansher, MBBS², Yashita Arora, MBBS⁴, Wania Moeen, MBBS², Kamran Khan, MBBS^2
1DOW University of Health Sciences, Karachi, Sindh, Pakistan; ²DOW University of Health Sciences, Washington, DC; ³The George Washington University School of Medicine and Health Sciences, Washington, DC; ⁴Rajiv Gandhi Medical College, Washington, DC

Introduction: Peptic Ulcer Disease (PUD) is a common GI condition that can give rise to several potentially life-threatening complications such as upper GI bleeding and perforation. However, PUD-related mortality trends in adults have not been investigated. The aim of our study is to examine trends in PUD-related mortality in the U.S. from 1999 to 2020.

Methods: We used the CDC-WONDER (Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research) database to examine PUD-related mortality trends from 1999 to 2020 in individuals aged >=15. Age-adjusted mortality Rates (AAMRs) per 1 million people were calculated for the total population and stratified by year, sex, age, and census region. Moreover, Annual Percentage Change (APC) was calculated for each stratum using the Joinpoint Regression Software.

Results: Between 1999 and 2020, there were a total of 65,846 PUD-related deaths in the U.S. The overall AAMR decreased rapidly from 27.2 in 1999 to 11.5 in 2007 (APC: -10.01; 95% CI: -11.81 to -9.45), after which it then fell to 6.8 in 2014 (APC: -7.77; 95%CI: -9.06 to -4.10). From 2014 onwards, AAMR plateaued at around 6.1 till 2020. While both males and females showed a decrease in AAMRs, (Average APC: -7.1; 95% CI: -7.13 to -6.54) and (Average APC: -6.80; 95% CI: -7.13 to -6.54) respectively, males had consistently higher mortality rates than females between 1999 (AAMR males: 34.2 vs. females: 22.6) and 2020 (AAMR males: 7.2 vs females: 5.4). Furthermore, adults ≥ 75 years of age had substantially higher AAMRs relative to individuals of younger age groups from 1999 (AAMR adults ≥ 75 years: 249.7 vs. adults aged 45-74: 20.7 vs. young adults 15-44: 0.7) to 2020 (AAMR adults ≥ 75 years: 46.8 vs. adults aged 45-74: 6.3 vs. young adults 15-44: 0.4). When stratified by region, the West had the highest mortality rate (AAMR: 13.7) whereas the northeast had the lowest (AAMR: 9.5).

Discussion: Ensuing a period of substantial decline from 1999 to 2014, PUD-related mortality in U.S. adults has remained fairly constant. The highest AAMRs were observed among individuals aged ≥ 75 years, males, and among patients residing in the western region of the country. Therefore, to further decrease PUD-related mortality, it is imperative to implement targeted strategies to better prevent and manage PUD in elderly individuals. Similarly, steps should be taken to overcome any potential disparities in the regional standard of care provided to PUD patients.



Disclosures:


Muhammad Sohaib Khan, ¹, Mohammad Danish, MBBS², Muzamil Khan, MBBS³, Umar Mahmood, MBBS², Muhammad Jansher, MBBS², Yashita Arora, MBBS⁴, Wania Moeen, MBBS², Kamran Khan, MBBS². P2449 - A Two-Decade Analysis of Peptic Ulcer Mortality in the U.S (1999-2020), ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.