P2153 - From Past to Present: Analyzing 30 Years of Colorectal Cancer Incidence Trends in Ages 40-49 Years (1990-2021)

Romina Nomigolzar, MD¹, Hassam Ali, MD¹, Waqas Rasheed, MD², Abddulazeez Swaiti, MD³, Shiza sarfraz, MD¹, Umar Hayat, MD⁴, Dushyant S. Dahiya, MD⁵, Amna Iqbal, MD⁶, Manesh Kumar Gangwani, MD⁷, Fouad Jaber, MD⁸, Sheena shamoon, MD⁹, Douglas Adler, MD^10
1East Carolina University Brody School of Medicine, Greenville, NC; ²University of Kentucky, Lexington, KY; ³ECU Health, Greenville, NC; ⁴Geisinger Wyoming Valley Medical Center, Wilkes-Barre, PA; ⁵The University of Kansas School of Medicine, Kansas City, KS; ⁶University of Toledo Medical Center, Toledo, OH; ⁷University of Toledo, Toledo, OH; ⁸University of Missouri - Kansas City School of Medicine, Kansas City, MO; ⁹Rawalpindini Medical College, Lahore, Punjab, Pakistan; ¹⁰Center for Advanced Therapeutic (CATE), Centura Health, Porter Adventist Hospital, Peak Gastroenterology, Denver, CO

Introduction: The incidence of colorectal cancer (CRC) has been rising among younger adults, necessitating a detailed examination of trends. This study utilizes data from the Global Burden of Disease (GBD) database from 1990 to 2021 to analyze CRC incidence and mortality in the United States for individuals aged 40-49, focusing on gender-based differences.

Methods: Data from the GBD database were used to examine CRC incidence rates per 100,000 individuals, adjusting for population age distribution. Data were stratified by gender. Joinpoint software was used to assess temporal trends in the Average Percent Change (APC) and Average Annual Percent Change (AAPC). Log-linear regression models were employed to evaluate trends, and the Empirical Quantile Confidence Interval method was used to provide 95% confidence intervals.

Results: For ages 40-44, there were 137,317 incident CRC cases. Incidence increased from 15.88 to 21.69 per 100,000 (AAPC 0.98%, 95% CI: 0.85 to 1.10). For females, rates rose from 14.33 to 19.41 per 100,000 (AAPC 0.96%, 95% CI: 0.87 to 1.04). For males, rates increased from 17.47 to 24.02 per 100,000 (AAPC 1.05%, 95% CI: 0.94 to 1.17). Mortality increased from 4.88 to 5.01 per 100,000, with a slight decrease in females and an increase in males.
For ages 45-49, there were 240,756 incident CRC cases. Incidence increased from 30.63 to 40.15 per 100,000 (AAPC 0.94%, 95% CI: 0.88 to 0.99). For females, rates rose from 27.58 to 34.59 per 100,000 (AAPC 0.75%, 95% CI: 0.66 to 0.85). For males, rates increased from 33.79 to 45.86 per 100,000 (AAPC 1.08%, 95% CI: 0.98 to 1.19). Mortality decreased from 10.19 to 10.04 per 100,000, with decreases in females and increases in males.

Discussion: CRC incidence among adults aged 40-49 has shown a significant increase over the past three decades, with gender differences evident. These trends underscore the importance of targeted screening and prevention efforts for younger adults.



Disclosures:


Romina Nomigolzar, MD¹, Hassam Ali, MD¹, Waqas Rasheed, MD², Abddulazeez Swaiti, MD³, Shiza sarfraz, MD¹, Umar Hayat, MD⁴, Dushyant S. Dahiya, MD⁵, Amna Iqbal, MD⁶, Manesh Kumar Gangwani, MD⁷, Fouad Jaber, MD⁸, Sheena shamoon, MD⁹, Douglas Adler, MD¹⁰. P2153 - From Past to Present: Analyzing 30 Years of Colorectal Cancer Incidence Trends in Ages 40-49 Years (1990-2021), ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.