P1956 - Diabetes Mellitus and Colorectal Cancer in a Hispanic Population of Puerto Rico

Esther Torres, MD, Felix Aponte Santos, MD, Paola Lozada Morena, BA
University of Puerto Rico School of Medicine, San Juan, Puerto Rico

Introduction: CRC is the leading cause of cancer death, and second most commonly diagnosed cancer in Puerto Rico. CRC is a multifactorial disease resulting from lifestyle, environmental, and genetics factors. Type 2 diabetes mellitus (T2DM), with a global prevalence of 8.4% and 12.4% among Puerto Ricans, has been associated with CRC. Deng et al. established the relationship of diabetes mellitus and insulin use with an increased risk of CRC in men and women. Giouleme et al established the relationship of diabetes mellitus and CRC through possible common pathophysiological and molecular mechanisms. There is only one study in Puerto Rico that evaluates the association of colorectal neoplasia in patients with diabetes mellitus. Our study analyzes our institution’s colonoscopy database for an association between diabetes mellitus and colorectal cancer among Puerto Ricans.

Methods: Medical records of patients in the Colonoscopy Registry Database of the Gastroenterology Endoscopy Unit at the University District Hospital and the clinics of the UPR School of Medicine from 2014-2017 were reviewed. Demographic data including age and gender, and medical history of CRC and DM were collected. Inferential statistics using Chi-Square and Mann-Whitney were used to determine associations between the variables.

Results: A total of 983 participants were included in the study with a mean age of 63 years (SD 13). Six hundred and eleven participants were females (62.2%). Three hundred and seventy-two participants were male (37.8%). Among the sample population, two hundred and forty-two (24.6%) were found with DM and eighty-three participants (8.4%) were found with CRC. A total of twenty-nine (34.94%) patients were found with DM and CRC. and two hundred and thirteen participants (23.67%) with DM only (P= 0.230).

Discussion: No association was found between DM and CRC in the sample population of this study. Given the high prevalence of DM and CRC in Puerto Rico, furthers studies are needed to confirm our findings and develop strategies to address preventive and healthcare policies for these diseases.




Disclosures:


Esther Torres, MD, Felix Aponte Santos, MD, Paola Lozada Morena, BA. P1956 - Diabetes Mellitus and Colorectal Cancer in a Hispanic Population of Puerto Rico, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.