P1212 - Association of Hemolytic Anemia With Hepatitis B: A Comprehensive Analysis of Risk Factors, Morbidity, and Mortality Using National Inpatient Sample Data (2016-2019)

Mhd Kutaiba Albuni, MD¹, Bisher Sawaf, MD², Bana Sabbagh, MD³, Mohamad Hijazi, MD⁴, Shahem Abbarah, MD^5
1TriHealth, Doha, Ad Dawhah, Qatar; ²University of Toledo, Toledo, OH; ³TriHealth, Cincinnati, OH; ⁴TriHealth Good Samaritan Hospital, Cincinnati, OH; ⁵MedStar Health, Baltimore, MD

Introduction: Hemolytic anemia is a serious complication that affects Hepatitis B (HBV) patients. Investigating its risk factors, and impact on morbidity and mortality has yet to be discussed well in literature. We aim to provide extensive analysis using the national inpatient sample (NIS).

Methods: NIS data from 2016 to 2019 was used to identify HBV patients with hemolytic anemia. STATA x15 was used to conduct descriptive and inferential analyses, univariate, and multivariate regression. Baseline characteristics (age, sex, race, hospital payer, type of hospital) were tabulated in hemolytic versus nonhemolytic anemia patients. Our main outcomes were the prevalence of hemolytic anemia in HBV, its effect on death, and the length of stay (LOS).

Results: Our analysis has identified 3797 patients with HBV; among them, 42 patients developed hemolytic anemia with a peak occurrence in 2017 and 2019. Univariate regression showed a significant association between HBV and hemolytic anemia (OR: 1.44, p=0.017, 95% CI: 1.06-1.96). Mortality rate and LOS were substantially higher in HBV patients with hemolytic anemia compared to non-hemolytic HBV patients (OR: 4.46, p< 0.001, CI: 1.84-10.77), and (coefficient: 6.22, p< 0.001, 95% CI: 3.19-3.24) respectively. After adjustment through multivariate regression, mortality rate, and LOS remain statistically significant (OR: 4.55, p=0.001, 95% CI: 1.83-11.28) and cof: 6.05, p< 0.001, 95% CI: 3.05 - 9.06). Underlying cirrhosis, hypertension, diabetes mellitus, and female gender showed significant association with developing hemolytic anemia.

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Discussion: Our study reveals a strong link between Hepatitis B and hemolytic anemia, accentuated by risk factors such as cirrhosis, hypertension, diabetes, and female gender. The increased mortality and prolonged hospital stay persist after adjusting for confounding variables, emphasizing the critical need for vigilant management and targeted interventions in Hepatitis B patients with hemolytic anemia.


Disclosures:


Mhd Kutaiba Albuni, MD¹, Bisher Sawaf, MD², Bana Sabbagh, MD³, Mohamad Hijazi, MD⁴, Shahem Abbarah, MD⁵. P1212 - Association of Hemolytic Anemia With Hepatitis B: A Comprehensive Analysis of Risk Factors, Morbidity, and Mortality Using National Inpatient Sample Data (2016-2019), ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.