Yuqi Guo, PhD1, Jingyi Shi, PhD2, Hongke Wu, MD, MPH, MS3, Mohammad Alabbas, MD4, Shreya Sengupta, MD5, Omar T. Sims, PhD6 1University of North Carolina at Charlotte, Charlotte, NC; 2Mississippi State University, Starkville, MS; 3Case Western Reserve University, Cleveland, OH; 4University of Debrecen, Debrecen, Hajdu-Bihar, Hungary; 5Cleveland Clinic Foundation, Cleveland, OH; 6Cleveland Clinic, Cleveland, OH
Introduction: Alcohol is a pernicious accelerant of advanced liver disease among people living with hepatitis C (HCV). The objectives of this population-level analysis were to estimate the prevalence of alcohol use over an 11-year period among people living with HCV in the United States, to examine changes in the trends of alcohol use among people living with HCV, and to identify independent predictors of alcohol use.
Methods: We combined and analyzed 6 annual cycles of weighted data (2007-2018) collected by the National Health and Nutrition Examination Survey from people living with HCV.
Results: The prevalence of alcohol use among people living with HCV in the US from 2007-2018 was 67% (CI 60%-74%). Trends in alcohol use increased significantly from 38% (CI 18%-61%) in 2007-2008 to 87% (CI 57%-99%) in 2017-2018 among those > high school education (trend P=0.032), from 56% (CI 22%-86%) in 2007-2008 to 93% in 2017-2018 among those with cannabis use (trend P=0.02), and from 64% (14%-97%) in 2007-2008 to 84% (CI 42%-99%) among those with depression (trend P=0.04). In multivariate analysis, cannabis use (OR=2.60 CI 1.05-6.45, p=0.4) was positively associated with alcohol use, and ≥10 yearly health care visits (OR=0.31 CI 0.13-0.72, p=0.01) was negatively associated with alcohol use.
Discussion: Alcohol use among people living with HCV is markedly high, and it is increasing year over year. Clinical and public health efforts are needed to inform people living with HCV of the harmful effects of alcohol use and to link them to harm reduction or cessation approaches.
Disclosures:
Yuqi Guo indicated no relevant financial relationships.
Jingyi Shi indicated no relevant financial relationships.
Hongke Wu indicated no relevant financial relationships.
Mohammad Alabbas indicated no relevant financial relationships.
Shreya Sengupta indicated no relevant financial relationships.
Omar Sims indicated no relevant financial relationships.
Yuqi Guo, PhD1, Jingyi Shi, PhD2, Hongke Wu, MD, MPH, MS3, Mohammad Alabbas, MD4, Shreya Sengupta, MD5, Omar T. Sims, PhD6. P1140 - Prevalence of Alcohol Use Among People Living with HCV in the United States: An 11-Year Epidemiologic Trends Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
