P1155 - Outcomes of Liver Cirrhosis Classified By Race: A 5-Year Nationwide Analysis

James R. Pellegrini, MD¹, Sean Na, MD², Zyrille Guiveses, BS², Andrej Sodoma, DO³, Samuel Greenberg, BA⁴, Tulika Saggar, MD⁵, Atul Sinha, MD^5
1Nassau University Medical Center, Great River, NY; ²Renaissance School of Medicine at Stony Brook University, Great Neck, NY; ³South Shore University Hospital, Bay Shore, NY; ⁴Renaissance School of Medicine at Stony Brook University, Stony Brook, NY; ⁵Nassau University Medical Center, East Meadow, NY

Introduction: Four million people in the U.S. are affected by liver cirrhosis (LC). It is estimated that minority populations comprise less than 25% of the total U.S. population. This study aims to see the effects of LC in these minority groups.

Methods: The National Inpatient Sample (NIS) from 2016 to 2020 was used to identify adult hospitalizations with a primary diagnosis of LC through International Classification of Diseases, Tenth Revision (ICD-10) codes. LC patients were classified by race and analyzed for baseline characteristics: age, gender, insurance status, patient location, median household income in patient zip code, and various comorbidities. Outcomes of interest were death, length of stay, and hospital charges focusing on racial disparities. Whites are the baseline group. A binomial generalized linear model with a logit link function was used to develop odds ratios for mortality, adjusted for confounders. Tweedie generalized linear models with a log link function were used to calculate relative differences, also adjusted for confounders.





Results: 515,900 LC admissions were included in this study: 339,765 were White, 42,485 were Black, 98,450 were Hispanic, 8,990 were Asian/Pacific Islander, 8,415 were Native American, and 17,795 were unspecified. All groups had mean ages ranging from 50 to 60. Males comprised the majority of all groups, with more than 54% in each one. Most were on Medicare/Medicaid. Whites have the highest percentage on Medicare (37.73%). Native Americans have the highest percentage on Medicaid (53.99%). Metropolitan areas (population >1 million) comprised mostly Black, Hispanic, and Asian/Pacific Islanders with 49.72%, 54.68%, 57.20%, respectively. Blacks were found with the highest percentage of acute kidney failure (32.34%), end-stage renal disease (8.89%), heart failure (20.39%), and hypertension (33.05%). We found that Blacks admitted with LC had significantly higher odds of mortality (OR 1.35, confidence interval (CI) 1.20 - 1.50) compared to Whites. Hispanics had lower odds of mortality (OR 0.89, CI 0.81 - 0.97) compared to Whites. Minorities hospitalized with LC had significantly different outcomes when compared to Whites. Compared to Whites, Blacks had a 34% higher odds of mortality, and Hispanics had an 11% lower odds of mortality.

Discussion: This study aims to bring more attention to minority populations in the U.S. and further studies to lessen the racial disparities seen in these minority populations.


Disclosures:


James R. Pellegrini, MD¹, Sean Na, MD², Zyrille Guiveses, BS², Andrej Sodoma, DO³, Samuel Greenberg, BA⁴, Tulika Saggar, MD⁵, Atul Sinha, MD⁵. P1155 - Outcomes of Liver Cirrhosis Classified By Race: A 5-Year Nationwide Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.