P0845 - The Association Between Co-Morbid Irritable Bowel Syndrome and Outcomes in Hospitalized Patients With Inflammatory Bowel Disease

Rahul Chaudhry, ¹, Binyamin R. Abramowitz, MD², Sushil Ahlawat, MD, MS, MBBS^3
1SUNY Downstate Health Sciences University, Woodbury, NY; ²SUNY Downstate Health Sciences University, New York, NY; ³SUNY Downstate Health Sciences University, Brooklyn, NY

Introduction: Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS) are two distinct conditions of the gastrointestinal tract that can coexist in up to 40% of patients. While there is significant research exploring the pathophysiology and disease course of IBD and IBS, individually, there are minimal studies considering how patients with both conditions may differ from those with only one of the aforementioned diagnoses. This study seeks to explore whether co-morbid IBS is an risk factor for worse outcomes in hospitalized IBD patients.

Methods: The 2020 National Inpatient Sample (NIS) database was utilized to conduct a retrospective, cross-sectional analysis of hospitalized patients. Patients were separated into two categories, ‘IBD, alone’ and ‘IBD+IBS,’ using their associated ICD-10 codes. Demographic data and complications/outcomes during hospitalization were compared between these two groups.

Results: 62,481 patients hospitalized with IBD were identified, among which 62,104 had ‘IBD, alone’ and 377 had ‘IBD+IBS.’ Notably, patients with both IBD and IBS had a 1.83x greater odds of colectomy/proctocolectomy during hospitalization when compared to those with only IBD . On the other hand, there were significantly increased rates of sepsis (12.25% vs 7.96%, p< 0.05) and respiratory failure (10.39% vs 6.70%, p< 0.05) in the ‘IBD, alone’ subgroup. There was no significant difference in mortality, pulmonary embolism, myocardial infarction, acute renal failure, length of stay, and hospitalization cost between the groups.

Discussion: In this retrospective, cross-sectional study of hospitalized patients with IBD in 2020, it was determined that IBS is associated with an increased odds of surgical intervention and decreased odds of sepsis and respiratory failure in patients with IBD. The results are in accordance with a prior study by Fu et al. (2023) that found a similarly increased odds of surgical intervention in patients with both conditions. A possible explanation for these results is the increased predisposition for unnecessary surgery in patients with IBS. There is also significant overlap between IBS and IBD symptoms, including gut barrier functional impairment and disturbance of gut microbiota, indicating that patients with both diagnoses may simply represent an IBD subgroup with more severe symptoms. Further research exploring the poorly understood pathophysiology of these conditions may shed light onto how they interact with one another the ideal management plan.


Disclosures:


Rahul Chaudhry, ¹, Binyamin R. Abramowitz, MD², Sushil Ahlawat, MD, MS, MBBS³. P0845 - The Association Between Co-Morbid Irritable Bowel Syndrome and Outcomes in Hospitalized Patients With Inflammatory Bowel Disease, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.