Universidad Autonoma de Bucaramanga Bucaramanga, Santander, Colombia
Juan Martin. Betancur Calderon, 1, German Manuel Tovar Fierro, 2, Miguel Enrique. Ochoa Vera, 1, Maria L. Luna-Gonzalez, 1, Juan Pablo. Baez Duarte, 1, Johan Ricardo. Gonzalez Rodriguez, MD1, Diana Carolina Ospina Galeano, 3 1Universidad Autonoma de Bucaramanga, Bucaramanga, Santander, Colombia; 2Fundacion Oftalmologica de Santander FOSCAL, Bucaramanga, Santander, Colombia; 3Universidad Autónoma de Bucaramanga, Bucaramanga, Santander, Colombia
Introduction: In the United States, 40.6% of colorectal cancer (CRC) cases between 2000-2016 were diagnosed at invasive stages (CCRI), while in Colombia, this feature has ranged from 53.5% in 2018 to 65% in 2021. Therefore, it is important to investigate the factors associated with CRC diagnosis at these stages in our region.
Methods: An observational and analytical cross-sectional study was conducted by secondary analysis of an anonymized database of biopsies obtained from colonoscopies performed by the Gastroenterology Service of Clínica Foscal, from July 1, 2016, to June 30, 2021. Prevalence ratio (PR) calculation was performed for CCRI in relation to clinical, demographic, and histopathological variables.
Results: A total of 538 records of patients diagnosed with de novo CRC were analyzed, with a median age of 66 years, mostly women (54.83%), with distal location (CCRD) in 65.06% and CCRI in 64.84% of cases. CCRI was more prevalent in those over 50 years old (82.80%) and in women (53.64%). The CCRI for proximal colorectal location had a PR of 1.06 (95% CI 0.93 – 1.20). A higher prevalence of CCRI was observed in the early presentation of CRC (p=0.04). CCRI was associated with abdominal/rectal pain, weight loss, and anemia (p < 0.001), change in stool characteristics and ascites (p=0.006); with weight loss being the factor with the strongest association (PR: 1.90, 95% CI 1.62–2.23). Histologically, moderate differentiation had a PR of 1.34 and poorly differentiated tumors a PR of 1.75 (p < 0.05). Additionally, the histological subtypes of signet ring and mucinous showed a PR of 1.15 with CCRI (p=0.04).
Discussion: No association was observed between the diagnosis of CCRI and its location in the colon. Early presentation of CRC, along with mucinous and signet ring histological subtypes, poorly and moderately differentiated tumors, symptoms such as abdominal and rectal pain, anemia, weight loss, presence of ascites, and changes in stool characteristics, are related to the presence of CCRI in our population.
Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
Disclosures:
Juan Betancur Calderon indicated no relevant financial relationships.
German Manuel Tovar Fierro indicated no relevant financial relationships.
Miguel Ochoa Vera indicated no relevant financial relationships.
Maria Luna-Gonzalez indicated no relevant financial relationships.
Juan Baez Duarte indicated no relevant financial relationships.
Johan Gonzalez Rodriguez indicated no relevant financial relationships.
Diana Carolina Ospina Galeano indicated no relevant financial relationships.
Juan Martin. Betancur Calderon, 1, German Manuel Tovar Fierro, 2, Miguel Enrique. Ochoa Vera, 1, Maria L. Luna-Gonzalez, 1, Juan Pablo. Baez Duarte, 1, Johan Ricardo. Gonzalez Rodriguez, MD1, Diana Carolina Ospina Galeano, 3. P0233 - Associated Factors With Invasive Stage of Colorectal Cancer in Patients Treated at a High Complexity Institution in Colombia, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
